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1

Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC)

Penning, Trevor M.

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 676 KB

english, 2015

2

Aldo-Keto Reductases and Bioactivation/Detoxication

Jin, Yi, Penning, Trevor M.

Journal:

Annual Review of Pharmacology

Year:

2007

Language:

english

File:

PDF, 433 KB

english, 2007

3

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Karen E. Knudsen, Trevor M. Penning

Journal:

Trends in Endocrinology & Metabolism

Year:

2010

Language:

english

File:

PDF, 449 KB

english, 2010

4

The Pattern of p53 Mutations Caused by PAH o -Quinones is Driven by 8-oxo-dGuo Formation while the Spectrum of Mutations is Determined by Biological Selection for Dominance

Park, Jong-Heum, Gelhaus, Stacy, Vedantam, Srilakshmi, Oliva, Andrea L., Batra, Abhita, Blair, Ian A., Troxel, Andrea B., Field, Jeffrey, Penning, Trevor M.

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 4.10 MB

english, 2008

5

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Jin, Yi, Chen, Mo, Penning, Trevor M.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 605 KB

english, 2014

6

[Vitamins and Hormones] Dehydroepiandrosterone Volume 108 || Dehydroepiandrosterone (DHEA)-SO 4 Depot and Castration-Resistant Prostate Cancer

Penning, Trevor M.

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

7

ChemInform Abstract: Enzyme Redesign

Trevor M. Penning, Joseph M. Jez

Journal:

Year:

2001

File:

PDF, 23 KB

2001

8

ChemInform Abstract: Regiospecific Oxidation of Polycyclic Aromatic Phenols to Quinones by Hypervalent Iodine Reagents.

Anhui Wu, Yazhen Duan, Daiwang Xu, Trevor M. Penning, Ronald G. Harvey

Journal:

Year:

2010

File:

PDF, 38 KB

2010

9

Anatomical and cellular localization of neuroactive 5α/3α-reduced steroid-synthesizing enzymes in the spinal cord

Christine Patte-Mensah, Trevor M. Penning, Ayikoe G. Mensah-Nyagan

Journal:

The Journal of Comparative Neurology

Year:

2004

Language:

english

File:

PDF, 1.32 MB

english, 2004

10

Nonsteroldal antiinflammatory drugs, vol. 5, chemistry and pharmacology of drugs. Edited by Joseph G. Lombardino; series editor is Daniel Lednicer. John Wiley and Sons, Inc., New York, NY 10158. 1985. 447 pp. 16 × 23.5 cm. ISBN: 0-471-89803-1

Trevor M. Penning

Journal:

Journal of Pharmaceutical Sciences

Year:

1986

Language:

english

File:

PDF, 310 KB

english, 1986

11

Anti-inflammatory compounds (clinical pharmacology series, volume 9). Edited by W. R. Nigel Williamson. 1987. Marcel Dekker: New York. 485 pp. ISBN: 0-8247-7602-x. $89.75

Trevor M. Penning

Journal:

Journal of Pharmaceutical Sciences

Year:

1987

Language:

english

File:

PDF, 109 KB

english, 1987

12

Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Adegoke O. Adeniji, Barry M. Twenter, Michael C. Byrns, Yi Jin, Jeffrey D. Winkler, Trevor M. Penning

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 833 KB

english, 2011

13

Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents

Anhui Wu, Yazhen Duan, Daiwang Xu, Trevor M. Penning, Ronald G. Harvey

Journal:

Year:

2010

Language:

english

File:

PDF, 842 KB

english, 2010

14

Synthesis of 13C2-benzo[a]pyrene and its 7,8-dihydrodiol and 7,8-dione implicated as carcinogenic metabolites

Chongzhao Ran, Daiwang Xu, Qing Dai, Trevor M. Penning, Ian A. Blair, Ronald G. Harvey

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 175 KB

english, 2008

15

Amino acid adducts of PAH o-quinones: model studies with naphthalene-1,2-dione

Gopishetty R Sridhar, Varanasi S Murty, Seon Hwa Lee, Ian A Blair, Trevor M Penning

Journal:

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

16

Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells

Mikhail G. Dozmorov, Robert E. Hurst, Daniel J. Culkin, Bradley P. Kropp, Mark Barton Frank, Jeanette Osban, Trevor M. Penning, Hsueh-Kung Lin

Journal:

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

17

Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

Qian Ruan, Hye-Young H. Kim, Hao Jiang, Trevor M. Penning, Ronald G. Harvey, Ian A. Blair

Journal:

Rapid Communications in Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 653 KB

english, 2006

18

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Trevor M. Penning, Michael C. Byrns

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 209 KB

english, 2009

19

Metabolism and Distribution of Benzo[ a ]pyrene-7,8-dione (B[ a ]P-7,8-dione) in Human Lung Cells by Liquid Chromatography Tandem Mass Spectrometry: Detection of an Adenine B[ a ]P-7,8-dione Adduct

Huang, Meng, Liu, Xiaojing, Basu, Sankha S., Zhang, Li, Kushman, Mary E., Harvey, Ronald G., Blair, Ian A., Penning, Trevor M.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1013 KB

english, 2012

20

Quantitation of Benzo[a]pyrene Metabolic Profiles in Human Bronchoalveolar (H358) Cells by Stable Isotope Dilution Liquid Chromatography–Atmospheric Pressure Chemical Ionization Mass Spectrometry

Lu, Ding, Harvey, Ronald G., Blair, Ian A., Penning, Trevor M.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

21

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.75 MB

english, 2003

22

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.67 MB

english, 2003

23

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated with Diabetic Complications

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.19 MB

english, 2003

24

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.83 MB

english, 2003

25

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Efficient Syntheses of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.24 MB

english, 2003

26

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldose Reductase and the Stress Response

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.47 MB

english, 2003

27

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.89 MB

english, 2003

28

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.59 MB

english, 2003

29

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Competing Reactions of Aflatoxin B 1 Dialdehyde: Enzymatic Reduction versus Adduction with Lysine

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 844 KB

english, 2003

30

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.49 MB

english, 2003

31

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from the Mouse

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.49 MB

english, 2003

32

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Aflatoxin Aldehyde Reductases

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.53 MB

english, 2003

33

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || The Use of Mammalian Cell Lines to Investigate the Role of Aldo-Keto Reductases in the Detoxication of Aldehydes and Ketones

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1.42 MB

english, 2003

34

[ACS Symposium Series] Aldo-Keto Reductases and Toxicant Metabolism Volume 865 || Chemistry of Polycyclic Aromatic Hydrocarbons (PAH) o -Quinones Generated by the Aldo-Keto Reductase Pathway of PAH Activation

Penning, Trevor M., Petrash, J. Mark

Year:

2003

Language:

english

File:

PDF, 1001 KB

english, 2003

35

Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione

Varanasi S. Murty, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

36

Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism

Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

1993

Language:

english

File:

PDF, 3.58 MB

english, 1993

37

Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon o-quinones produced by dihydrodiol dehydrogenase

Lynn Flowers-Geary, Wendy Bleczinski, Ronald G. Harvey, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

1996

Language:

english

File:

PDF, 1.31 MB

english, 1996

38

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

Michael C. Byrns, Stephan Steckelbroeck, Trevor M. Penning

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 580 KB

english, 2008

39

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

Mo Chen, Adegoke O. Adeniji, Barry M. Twenter, Jeffrey D. Winkler, David W. Christianson, Trevor M. Penning

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

40

Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): Role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs

Michael C. Byrns, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

41

Aldo-keto reductases in which the conserved catalytic histidine is substituted

Luigi Di Costanzo, Trevor M. Penning, David W. Christianson

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 1.67 MB

english, 2009

42

The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function

Rebekka Mindnich, Jason E. Drury, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

43

Engineering steroid hormone specificity into aldo-keto reductases

Trevor M Penning, Haiching Ma, Joseph M Jez

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 352 KB

english, 2001

44

Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)

Nisha T. Palackal, Michael E. Burczynski, Ronald G. Harvey, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

45

The aldo-keto reductase (AKR) superfamily: an update

Joseph M. Jez, Trevor M. Penning

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 1.64 MB

english, 2001

46

Steroid-binding site residues dictate optimal substrate positioning in rat 3α-hydroxysteroid dehydrogenase (3α-HSD or AKR1C9)

Vladi V Heredia, Ryan G Kruger, Trevor M Penning

Journal:

Chemico-Biological Interactions

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

47

Role of human type 3 3α-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells

Tea Lanišnik Rižner, Hsueh K Lin, Trevor M Penning

Journal:

Chemico-Biological Interactions

Year:

2003

Language:

english

File:

PDF, 359 KB

english, 2003

48

The aldo-keto reductase superfamily homepage

David Hyndman, David R Bauman, Vladi V Heredia, Trevor M Penning

Journal:

Chemico-Biological Interactions

Year:

2003

Language:

english

File:

PDF, 729 KB

english, 2003

49

Examination of the differences in structure–function of human and rat 3α-hydroxysteroid dehydrogenase

Yi Jin, William C Cooper, Trevor M Penning

Journal:

Chemico-Biological Interactions

Year:

2003

Language:

english

File:

PDF, 455 KB

english, 2003

50

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase

Melanie J Bennett, Ross H Albert, Joseph M Jez, Haiching Ma, Trevor M Penning, Mitchell Lewis

Journal:

Year:

1997

Language:

english

File:

PDF, 289 KB

english, 1997